Search results for " chromatography column"
Article
Making the Move to Continuous Chromatography
Making the Move to Continuous Chromatography
Early adopters are benefiting from lower costs and increased productivity.
By Cynthia A. Challener
Tashatuvango/Shu…
Article
Optimizing Resin Performance with Disposable Chromatography Solutions
The experts addressed how disposable chromatography columns can be used throughout the life of a campaign, the costs and benefits associated with using prepacked columns, the complexities of resin str…
Article
Process Chromatography Selection for Downstream Processing Applications
BioPharm: What are some common chromatography column issues one might experience? How can these issues be addressed?
Björkman (Cytiva): Some common chromatography column issues include:
• Colu…
Article
Improving Process-Scale Chromatography
The commercial-scale unit has up to eight chromatography columns in the single-use flow path and the ability to purify target biomolecules from bioreactors up to 2000 L in size within a 24-hour operat…
Article
Reducing Cross-Contamination Risks in Process Chromatography
The company is working with Amgen to test the performance of a custom-designed, 3D-printed chromatography column to determine if it can be used in Amgen’s R&D efforts to develop improved processes for…
Article
A Look at the Affinity Chromatography Landscape
A Look at the Affinity Chromatography Landscape
New ligands are being developed to meet the separation and purification needs of next-gen biologics.
By Cynthia A. Challener
…
Article
Process Chromatography: Continuous Optimization
Improved resin chemistries and customized separation solutions are enabling more efficient separations.
By Cynthia A. Challener
Cell-culture and fermentation are high-…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Figure 2: A typical setup of a bioreactor system model along with a chromatography column. The delay volumes are modeled as a chain of continuous stirred tank (CSTR) and dispersed plug flow (DPFR) rea…
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
If used correctly, these new analytical methods can reduce analysis and product development time.
ABSTRACT
Monoclonal antibodies represent a significant portion of sales in the biopharma…
Article
Technology Innovations Improve Process Chromatography Performance
“Traditional, resin-based chromatography columns are often oversized due to throughput limitations and are ill-suited to flexible manufacturing. These factors impose challenges on the design of purifi…